Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.
Identifieur interne : 000742 ( Main/Exploration ); précédent : 000741; suivant : 000743Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.
Auteurs : F. Mateo [Espagne] ; E J Arenas [Espagne] ; H. Aguilar [Espagne] ; J. Serra-Musach [Espagne] ; G Ruiz De Garibay [Espagne] ; J. Boni [Espagne] ; M. Maicas [Espagne] ; S. Du [États-Unis] ; F. Iorio [Royaume-Uni] ; C. Herranz-Ors [Espagne] ; A. Islam [Bangladesh] ; X. Prado [Espagne] ; A. Llorente [Espagne] ; A. Petit [Espagne] ; A. Vidal [Espagne] ; I. Català [Espagne] ; T. Soler [Espagne] ; G. Venturas [Espagne] ; A. Rojo-Sebastian [Espagne] ; H. Serra [Espagne] ; D. Cuadras [Espagne] ; I. Blanco [Espagne] ; J. Lozano [Espagne] ; F. Canals [Espagne] ; A M Sieuwerts [Pays-Bas] ; V. De Weerd [Pays-Bas] ; M P Look [Pays-Bas] ; S. Puertas [Espagne] ; N. García [Espagne] ; A S Perkins [États-Unis] ; N. Bonifaci [Espagne] ; M. Skowron [Espagne] ; L. G Mez-Bald [Espagne] ; V. Hernández [Espagne] ; A. Martínez-Aranda [Espagne] ; M. Martínez-Iniesta [Espagne] ; X. Serrat [Espagne] ; J. Cer N [Espagne] ; J. Brunet [Espagne] ; M P Barretina [Espagne] ; M. Gil [Espagne] ; C. Falo [Espagne] ; A. Fernández [Espagne] ; I. Morilla [Espagne] ; S. Pernas [Espagne] ; M J Plà [Espagne] ; X. Andreu [Espagne] ; M A Seguí [Espagne] ; R. Ballester [Espagne] ; E. Castellà [Espagne] ; M. Nellist [Pays-Bas] ; S. Morales [Espagne] ; J. Valls [Espagne] ; A. Velasco [Espagne] ; X. Matias-Guiu [Espagne] ; A. Figueras [Espagne] ; J V Sánchez-Mut [Espagne] ; M. Sánchez-Céspedes [Espagne] ; A. Cordero [Espagne] ; J. G Mez-Miragaya [Espagne] ; L. Palomero [Espagne] ; A. G Mez [Espagne] ; T F Gajewski [États-Unis] ; E E W. Cohen [États-Unis] ; M. Jesiotr [Pologne] ; L. Bodnar [Pologne] ; M. Quintela-Fandino [Espagne] ; N. L Pez-Bigas [Espagne] ; R. Valdés-Mas [Espagne] ; X S Puente [Espagne] ; F. Vi Als [Espagne] ; O. Casanovas [Espagne] ; M. Graupera [Espagne] ; J. Hernández-Losa [Espagne] ; S. Ram N Y Cajal [Espagne] ; L. García-Alonso [Royaume-Uni] ; J. Saez-Rodriguez [Royaume-Uni] ; M. Esteller [Espagne] ; A. Sierra [Espagne] ; N. Martín-Martín [Espagne] ; A. Matheu [Espagne] ; A. Carracedo [Espagne] ; E. González-Suárez [Espagne] ; M. Nanjundan [États-Unis] ; J. Cortés [Espagne] ; C. Lázaro [Espagne] ; M D Odero [Espagne] ; J W M. Martens [Pays-Bas] ; G. Moreno-Bueno [Espagne] ; M H Barcellos-Hoff [États-Unis] ; A. Villanueva [Espagne] ; R R Gomis [Espagne] ; M A Pujana [Espagne]Source :
- Oncogene [ 1476-5594 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Cellules MCF-7 (MeSH), Facteur de transcription SOX-9 (génétique), Facteurs de transcription (génétique), Femelle (MeSH), Humains (MeSH), Métastase tumorale (MeSH), Ostéonectine (génétique), Prolifération cellulaire (génétique), Proto-oncogènes (génétique), Protéine de régulation associée à mTOR (MeSH), Protéine du locus du complexe MDS1 et EVI1 (MeSH), Protéines adaptatrices de la transduction du signal (génétique), Protéines de liaison à l'ADN (génétique), Protéines de transport (génétique), Protéines des microfilaments (génétique), Régulation de l'expression des gènes tumoraux (MeSH), Sujet âgé (MeSH), Sérine-thréonine kinases TOR (antagonistes et inhibiteurs), Sérine-thréonine kinases TOR (génétique), Tests d'activité antitumorale sur modèle de xénogreffe (MeSH), Transduction du signal (génétique), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (génétique), Tumeurs du poumon (secondaire), Tumeurs du sein (anatomopathologie), Tumeurs du sein (génétique).
- MESH :
- anatomopathologie : Tumeurs du poumon, Tumeurs du sein.
- antagonistes et inhibiteurs : Sérine-thréonine kinases TOR.
- génétique : Facteur de transcription SOX-9, Facteurs de transcription, Ostéonectine, Prolifération cellulaire, Proto-oncogènes, Protéines adaptatrices de la transduction du signal, Protéines de liaison à l'ADN, Protéines de transport, Protéines des microfilaments, Sérine-thréonine kinases TOR, Transduction du signal, Tumeurs du poumon, Tumeurs du sein.
- secondaire : Tumeurs du poumon.
- Adulte, Adulte d'âge moyen, Cellules MCF-7, Femelle, Humains, Métastase tumorale, Protéine de régulation associée à mTOR, Protéine du locus du complexe MDS1 et EVI1, Régulation de l'expression des gènes tumoraux, Sujet âgé, Tests d'activité antitumorale sur modèle de xénogreffe.
English descriptors
- KwdEn :
- Adaptor Proteins, Signal Transducing (genetics), Adult (MeSH), Aged (MeSH), Breast Neoplasms (genetics), Breast Neoplasms (pathology), Carrier Proteins (genetics), Cell Proliferation (genetics), DNA-Binding Proteins (genetics), Female (MeSH), Gene Expression Regulation, Neoplastic (MeSH), Humans (MeSH), Lung Neoplasms (genetics), Lung Neoplasms (pathology), Lung Neoplasms (secondary), MCF-7 Cells (MeSH), MDS1 and EVI1 Complex Locus Protein (MeSH), Microfilament Proteins (genetics), Middle Aged (MeSH), Neoplasm Metastasis (MeSH), Osteonectin (genetics), Proto-Oncogenes (genetics), Regulatory-Associated Protein of mTOR (MeSH), SOX9 Transcription Factor (genetics), Signal Transduction (genetics), TOR Serine-Threonine Kinases (antagonists & inhibitors), TOR Serine-Threonine Kinases (genetics), Transcription Factors (genetics), Xenograft Model Antitumor Assays (MeSH).
- MESH :
- chemical , antagonists & inhibitors : TOR Serine-Threonine Kinases.
- chemical , genetics : Adaptor Proteins, Signal Transducing, Carrier Proteins, DNA-Binding Proteins, Microfilament Proteins, Osteonectin, SOX9 Transcription Factor, TOR Serine-Threonine Kinases, Transcription Factors.
- genetics : Breast Neoplasms, Cell Proliferation, Lung Neoplasms, Proto-Oncogenes, Signal Transduction.
- pathology : Breast Neoplasms, Lung Neoplasms.
- secondary : Lung Neoplasms.
- Adult, Aged, Female, Gene Expression Regulation, Neoplastic, Humans, MCF-7 Cells, MDS1 and EVI1 Complex Locus Protein, Middle Aged, Neoplasm Metastasis, Regulatory-Associated Protein of mTOR, Xenograft Model Antitumor Assays.
Abstract
Inhibitors of the mechanistic target of rapamycin (mTOR) are currently used to treat advanced metastatic breast cancer. However, whether an aggressive phenotype is sustained through adaptation or resistance to mTOR inhibition remains unknown. Here, complementary studies in human tumors, cancer models and cell lines reveal transcriptional reprogramming that supports metastasis in response to mTOR inhibition. This cancer feature is driven by EVI1 and SOX9. EVI1 functionally cooperates with and positively regulates SOX9, and promotes the transcriptional upregulation of key mTOR pathway components (REHB and RAPTOR) and of lung metastasis mediators (FSCN1 and SPARC). The expression of EVI1 and SOX9 is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR targeting failure.
DOI: 10.1038/onc.2016.427
PubMed: 27991928
PubMed Central: PMC5442428
Affiliations:
- Bangladesh, Espagne, Pays-Bas, Pologne, Royaume-Uni, États-Unis
- Californie, Catalogne, Communauté de Madrid, Floride, Hollande-Méridionale, Illinois, État de New York
- Barcelone, Chicago, Madrid, Rotterdam, Tampa
- Université de Chicago, Université de Floride du Sud
Links toward previous steps (curation, corpus...)
Le document en format XML
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Mateo</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Arenas, E J" sort="Arenas, E J" uniqKey="Arenas E" first="E J" last="Arenas">E J Arenas</name><affiliation wicri:level="3"><nlm:affiliation>Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Aguilar, H" sort="Aguilar, H" uniqKey="Aguilar H" first="H" last="Aguilar">H. Aguilar</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Serra Musach, J" sort="Serra Musach, J" uniqKey="Serra Musach J" first="J" last="Serra-Musach">J. Serra-Musach</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="De Garibay, G Ruiz" sort="De Garibay, G Ruiz" uniqKey="De Garibay G" first="G Ruiz" last="De Garibay">G Ruiz De Garibay</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Boni, J" sort="Boni, J" uniqKey="Boni J" first="J" last="Boni">J. Boni</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Maicas, M" sort="Maicas, M" uniqKey="Maicas M" first="M" last="Maicas">M. Maicas</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Medical Research (CIMA) and Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Applied Medical Research (CIMA) and Department of Biochemistry and Genetics, University of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Du, S" sort="Du, S" uniqKey="Du S" first="S" last="Du">S. Du</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiation Oncology, New York University School of Medicine, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, New York University School of Medicine, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Iorio, F" sort="Iorio, F" uniqKey="Iorio F" first="F" last="Iorio">F. Iorio</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation></author><author><name sortKey="Herranz Ors, C" sort="Herranz Ors, C" uniqKey="Herranz Ors C" first="C" last="Herranz-Ors">C. Herranz-Ors</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Islam, A" sort="Islam, A" uniqKey="Islam A" first="A" last="Islam">A. Islam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh.</nlm:affiliation><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="Prado, X" sort="Prado, X" uniqKey="Prado X" first="X" last="Prado">X. Prado</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Llorente, A" sort="Llorente, A" uniqKey="Llorente A" first="A" last="Llorente">A. Llorente</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Petit, A" sort="Petit, A" uniqKey="Petit A" first="A" last="Petit">A. Petit</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Vidal, A" sort="Vidal, A" uniqKey="Vidal A" first="A" last="Vidal">A. Vidal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Catala, I" sort="Catala, I" uniqKey="Catala I" first="I" last="Català">I. Català</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Soler, T" sort="Soler, T" uniqKey="Soler T" first="T" last="Soler">T. Soler</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Venturas, G" sort="Venturas, G" uniqKey="Venturas G" first="G" last="Venturas">G. Venturas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rojo Sebastian, A" sort="Rojo Sebastian, A" uniqKey="Rojo Sebastian A" first="A" last="Rojo-Sebastian">A. Rojo-Sebastian</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, MD Anderson Cancer Center, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, MD Anderson Cancer Center, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Serra, H" sort="Serra, H" uniqKey="Serra H" first="H" last="Serra">H. Serra</name><affiliation wicri:level="3"><nlm:affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cuadras, D" sort="Cuadras, D" uniqKey="Cuadras D" first="D" last="Cuadras">D. Cuadras</name><affiliation wicri:level="3"><nlm:affiliation>Statistics Unit, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Statistics Unit, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Blanco, I" sort="Blanco, I" uniqKey="Blanco I" first="I" last="Blanco">I. Blanco</name><affiliation wicri:level="3"><nlm:affiliation>Hereditary Cancer Programme, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hereditary Cancer Programme, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lozano, J" sort="Lozano, J" uniqKey="Lozano J" first="J" last="Lozano">J. Lozano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Biology and Biochemistry, Málaga University, and Molecular Oncology Laboratory, Mediterranean Institute for the Advance of Biotechnology and Health Research (IBIMA), University Hospital Virgen de la Victoria, Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Molecular Biology and Biochemistry, Málaga University, and Molecular Oncology Laboratory, Mediterranean Institute for the Advance of Biotechnology and Health Research (IBIMA), University Hospital Virgen de la Victoria, Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Canals, F" sort="Canals, F" uniqKey="Canals F" first="F" last="Canals">F. Canals</name><affiliation wicri:level="3"><nlm:affiliation>ProteoRed-Instituto de Salud Carlos III, Proteomic Laboratory, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>ProteoRed-Instituto de Salud Carlos III, Proteomic Laboratory, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sieuwerts, A M" sort="Sieuwerts, A M" uniqKey="Sieuwerts A" first="A M" last="Sieuwerts">A M Sieuwerts</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Weerd, V" sort="De Weerd, V" uniqKey="De Weerd V" first="V" last="De Weerd">V. De Weerd</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Look, M P" sort="Look, M P" uniqKey="Look M" first="M P" last="Look">M P Look</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Puertas, S" sort="Puertas, S" uniqKey="Puertas S" first="S" last="Puertas">S. Puertas</name><affiliation wicri:level="3"><nlm:affiliation>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Garcia, N" sort="Garcia, N" uniqKey="Garcia N" first="N" last="García">N. García</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Perkins, A S" sort="Perkins, A S" uniqKey="Perkins A" first="A S" last="Perkins">A S Perkins</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bonifaci, N" sort="Bonifaci, N" uniqKey="Bonifaci N" first="N" last="Bonifaci">N. Bonifaci</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Skowron, M" sort="Skowron, M" uniqKey="Skowron M" first="M" last="Skowron">M. Skowron</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="G Mez Bald, L" sort="G Mez Bald, L" uniqKey="G Mez Bald L" first="L" last="G Mez-Bald">L. G Mez-Bald</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hernandez, V" sort="Hernandez, V" uniqKey="Hernandez V" first="V" last="Hernández">V. Hernández</name><affiliation wicri:level="3"><nlm:affiliation>Biological Clues of the Invasive and Metastatic Phenotype Laboratory, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Biological Clues of the Invasive and Metastatic Phenotype Laboratory, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martinez Aranda, A" sort="Martinez Aranda, A" uniqKey="Martinez Aranda A" first="A" last="Martínez-Aranda">A. Martínez-Aranda</name><affiliation wicri:level="3"><nlm:affiliation>Biological Clues of the Invasive and Metastatic Phenotype Laboratory, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Biological Clues of the Invasive and Metastatic Phenotype Laboratory, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martinez Iniesta, M" sort="Martinez Iniesta, M" uniqKey="Martinez Iniesta M" first="M" last="Martínez-Iniesta">M. Martínez-Iniesta</name><affiliation wicri:level="3"><nlm:affiliation>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Serrat, X" sort="Serrat, X" uniqKey="Serrat X" first="X" last="Serrat">X. Serrat</name><affiliation wicri:level="3"><nlm:affiliation>Cancer and Human Molecular Genetics, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer and Human Molecular Genetics, IDIBELL, Hospitalet de Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cer N, J" sort="Cer N, J" uniqKey="Cer N J" first="J" last="Cer N">J. Cer N</name><affiliation wicri:level="3"><nlm:affiliation>Cancer and Human Molecular Genetics, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer and Human Molecular Genetics, IDIBELL, Hospitalet de Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Brunet, J" sort="Brunet, J" uniqKey="Brunet J" first="J" last="Brunet">J. Brunet</name><affiliation wicri:level="1"><nlm:affiliation>Hereditary Cancer Programme, ICO, Girona Biomedical Research Institute (IDIBGI), Girona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hereditary Cancer Programme, ICO, Girona Biomedical Research Institute (IDIBGI), Girona</wicri:regionArea><wicri:noRegion>Girona</wicri:noRegion></affiliation></author><author><name sortKey="Barretina, M P" sort="Barretina, M P" uniqKey="Barretina M" first="M P" last="Barretina">M P Barretina</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBGI, Girona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBGI, Girona</wicri:regionArea><wicri:noRegion>Girona</wicri:noRegion></affiliation></author><author><name sortKey="Gil, M" sort="Gil, M" uniqKey="Gil M" first="M" last="Gil">M. Gil</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Falo, C" sort="Falo, C" uniqKey="Falo C" first="C" last="Falo">C. Falo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Fernandez, A" sort="Fernandez, A" uniqKey="Fernandez A" first="A" last="Fernández">A. Fernández</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Morilla, I" sort="Morilla, I" uniqKey="Morilla I" first="I" last="Morilla">I. Morilla</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pernas, S" sort="Pernas, S" uniqKey="Pernas S" first="S" last="Pernas">S. Pernas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pla, M J" sort="Pla, M J" uniqKey="Pla M" first="M J" last="Plà">M J Plà</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gynecology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Gynecology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Andreu, X" sort="Andreu, X" uniqKey="Andreu X" first="X" last="Andreu">X. Andreu</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Parc Taulí Hospital Consortium, Sabadell, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, Parc Taulí Hospital Consortium, Sabadell, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Segui, M A" sort="Segui, M A" uniqKey="Segui M" first="M A" last="Seguí">M A Seguí</name><affiliation wicri:level="3"><nlm:affiliation>Medical Oncology Service, Parc Taulí Hospital Consortium, Sabadell, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Medical Oncology Service, Parc Taulí Hospital Consortium, Sabadell, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ballester, R" sort="Ballester, R" uniqKey="Ballester R" first="R" last="Ballester">R. Ballester</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, University Hospital Germans Trias i Pujol, ICO, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Radiation Oncology, University Hospital Germans Trias i Pujol, ICO, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Castella, E" sort="Castella, E" uniqKey="Castella E" first="E" last="Castellà">E. Castellà</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital Germans Trias i Pujol, ICO, IGTP, Badalona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital Germans Trias i Pujol, ICO, IGTP, Badalona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Nellist, M" sort="Nellist, M" uniqKey="Nellist M" first="M" last="Nellist">M. Nellist</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Morales, S" sort="Morales, S" uniqKey="Morales S" first="S" last="Morales">S. Morales</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Valls, J" sort="Valls, J" uniqKey="Valls J" first="J" last="Valls">J. Valls</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Velasco, A" sort="Velasco, A" uniqKey="Velasco A" first="A" last="Velasco">A. Velasco</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Matias Guiu, X" sort="Matias Guiu, X" uniqKey="Matias Guiu X" first="X" last="Matias-Guiu">X. Matias-Guiu</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Figueras, A" sort="Figueras, A" uniqKey="Figueras A" first="A" last="Figueras">A. Figueras</name><affiliation wicri:level="3"><nlm:affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez Mut, J V" sort="Sanchez Mut, J V" uniqKey="Sanchez Mut J" first="J V" last="Sánchez-Mut">J V Sánchez-Mut</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez Cespedes, M" sort="Sanchez Cespedes, M" uniqKey="Sanchez Cespedes M" first="M" last="Sánchez-Céspedes">M. Sánchez-Céspedes</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cordero, A" sort="Cordero, A" uniqKey="Cordero A" first="A" last="Cordero">A. Cordero</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="G Mez Miragaya, J" sort="G Mez Miragaya, J" uniqKey="G Mez Miragaya J" first="J" last="G Mez-Miragaya">J. G Mez-Miragaya</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Palomero, L" sort="Palomero, L" uniqKey="Palomero L" first="L" last="Palomero">L. Palomero</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="G Mez, A" sort="G Mez, A" uniqKey="G Mez A" first="A" last="G Mez">A. G Mez</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Gajewski, T F" sort="Gajewski, T F" uniqKey="Gajewski T" first="T F" last="Gajewski">T F Gajewski</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Pathology and Medicine, University of Chicago, Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology and Medicine, University of Chicago, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Cohen, E E W" sort="Cohen, E E W" uniqKey="Cohen E" first="E E W" last="Cohen">E E W. Cohen</name><affiliation wicri:level="2"><nlm:affiliation>Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moores Cancer Center, University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jesiotr, M" sort="Jesiotr, M" uniqKey="Jesiotr M" first="M" last="Jesiotr">M. Jesiotr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Military Institute of Medicine, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pathology, Military Institute of Medicine, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Bodnar, L" sort="Bodnar, L" uniqKey="Bodnar L" first="L" last="Bodnar">L. Bodnar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Military Institute of Medicine, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Oncology, Military Institute of Medicine, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Quintela Fandino, M" sort="Quintela Fandino, M" uniqKey="Quintela Fandino M" first="M" last="Quintela-Fandino">M. Quintela-Fandino</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer Clinical Research Unit, Spanish National Cancer Research Center (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer Clinical Research Unit, Spanish National Cancer Research Center (CNIO), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="L Pez Bigas, N" sort="L Pez Bigas, N" uniqKey="L Pez Bigas N" first="N" last="L Pez-Bigas">N. L Pez-Bigas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Experimental and Health Sciences, Barcelona Biomedical Research Park, Pompeu Fabra University (UPF), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Experimental and Health Sciences, Barcelona Biomedical Research Park, Pompeu Fabra University (UPF), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Valdes Mas, R" sort="Valdes Mas, R" uniqKey="Valdes Mas R" first="R" last="Valdés-Mas">R. Valdés-Mas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, University Institute of Oncology of Asturias, University of Oviedo, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, University Institute of Oncology of Asturias, University of Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Puente, X S" sort="Puente, X S" uniqKey="Puente X" first="X S" last="Puente">X S Puente</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, University Institute of Oncology of Asturias, University of Oviedo, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, University Institute of Oncology of Asturias, University of Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Vi Als, F" sort="Vi Als, F" uniqKey="Vi Als F" first="F" last="Vi Als">F. Vi Als</name><affiliation wicri:level="3"><nlm:affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Casanovas, O" sort="Casanovas, O" uniqKey="Casanovas O" first="O" last="Casanovas">O. Casanovas</name><affiliation wicri:level="3"><nlm:affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Graupera, M" sort="Graupera, M" uniqKey="Graupera M" first="M" last="Graupera">M. Graupera</name><affiliation wicri:level="3"><nlm:affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hernandez Losa, J" sort="Hernandez Losa, J" uniqKey="Hernandez Losa J" first="J" last="Hernández-Losa">J. Hernández-Losa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, Vall d'Hebron University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ram N Y Cajal, S" sort="Ram N Y Cajal, S" uniqKey="Ram N Y Cajal S" first="S" last="Ram N Y Cajal">S. Ram N Y Cajal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, Vall d'Hebron University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Garcia Alonso, L" sort="Garcia Alonso, L" uniqKey="Garcia Alonso L" first="L" last="García-Alonso">L. García-Alonso</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Saez Rodriguez, J" sort="Saez Rodriguez, J" uniqKey="Saez Rodriguez J" first="J" last="Saez-Rodriguez">J. Saez-Rodriguez</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Esteller, M" sort="Esteller, M" uniqKey="Esteller M" first="M" last="Esteller">M. Esteller</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sierra, A" sort="Sierra, A" uniqKey="Sierra A" first="A" last="Sierra">A. Sierra</name><affiliation wicri:level="3"><nlm:affiliation>Molecular and Translational Oncology Laboratory, Biomedical Research Center CELLEX-CRBC, Biomedical Research Institute 'August Pi i Sunyer' (IDIBAPS), and Systems Biology Department, Faculty of Science and Technology, University of Vic, Central University of Catalonia, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Molecular and Translational Oncology Laboratory, Biomedical Research Center CELLEX-CRBC, Biomedical Research Institute 'August Pi i Sunyer' (IDIBAPS), and Systems Biology Department, Faculty of Science and Technology, University of Vic, Central University of Catalonia, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martin Martin, N" sort="Martin Martin, N" uniqKey="Martin Martin N" first="N" last="Martín-Martín">N. Martín-Martín</name><affiliation wicri:level="1"><nlm:affiliation>Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio</wicri:regionArea><wicri:noRegion>Derio</wicri:noRegion></affiliation></author><author><name sortKey="Matheu, A" sort="Matheu, A" uniqKey="Matheu A" first="A" last="Matheu">A. Matheu</name><affiliation wicri:level="1"><nlm:affiliation>Neuro-Oncology Section, Oncology Department, Biodonostia Research Institute, San Sebastian, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neuro-Oncology Section, Oncology Department, Biodonostia Research Institute, San Sebastian</wicri:regionArea><wicri:noRegion>San Sebastian</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Ikerbasque, Basque Foundation for Science, Bilbao, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Ikerbasque, Basque Foundation for Science, Bilbao</wicri:regionArea><wicri:noRegion>Bilbao</wicri:noRegion></affiliation></author><author><name sortKey="Carracedo, A" sort="Carracedo, A" uniqKey="Carracedo A" first="A" last="Carracedo">A. Carracedo</name><affiliation wicri:level="1"><nlm:affiliation>Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio</wicri:regionArea><wicri:noRegion>Derio</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Ikerbasque, Basque Foundation for Science, Bilbao, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Ikerbasque, Basque Foundation for Science, Bilbao</wicri:regionArea><wicri:noRegion>Bilbao</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Bilbao, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Bilbao</wicri:regionArea><wicri:noRegion>Bilbao</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Suarez, E" sort="Gonzalez Suarez, E" uniqKey="Gonzalez Suarez E" first="E" last="González-Suárez">E. González-Suárez</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Nanjundan, M" sort="Nanjundan, M" uniqKey="Nanjundan M" first="M" last="Nanjundan">M. Nanjundan</name><affiliation wicri:level="4"><nlm:affiliation>Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL</wicri:regionArea><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation></author><author><name sortKey="Cortes, J" sort="Cortes, J" uniqKey="Cortes J" first="J" last="Cortés">J. Cortés</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, VHIO, Vall d'Hebron University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, VHIO, Vall d'Hebron University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lazaro, C" sort="Lazaro, C" uniqKey="Lazaro C" first="C" last="Lázaro">C. Lázaro</name><affiliation wicri:level="3"><nlm:affiliation>Hereditary Cancer Programme, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hereditary Cancer Programme, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Odero, M D" sort="Odero, M D" uniqKey="Odero M" first="M D" last="Odero">M D Odero</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Medical Research (CIMA) and Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Applied Medical Research (CIMA) and Department of Biochemistry and Genetics, University of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Martens, J W M" sort="Martens, J W M" uniqKey="Martens J" first="J W M" last="Martens">J W M. Martens</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Moreno Bueno, G" sort="Moreno Bueno, G" uniqKey="Moreno Bueno G" first="G" last="Moreno-Bueno">G. Moreno-Bueno</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biochemistry, Autonomous University of Madrid (UAM), Biomedical Research Institute 'Alberto Sols' (Spanish National Research Council (CSIC)-UAM), Translational Research Laboratory, Hospital La Paz Institute for Health Research (IdiPAZ), and MD Anderson International Foundation, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry, Autonomous University of Madrid (UAM), Biomedical Research Institute 'Alberto Sols' (Spanish National Research Council (CSIC)-UAM), Translational Research Laboratory, Hospital La Paz Institute for Health Research (IdiPAZ), and MD Anderson International Foundation, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Barcellos Hoff, M H" sort="Barcellos Hoff, M H" uniqKey="Barcellos Hoff M" first="M H" last="Barcellos-Hoff">M H Barcellos-Hoff</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiation Oncology, New York University School of Medicine, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, New York University School of Medicine, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Villanueva, A" sort="Villanueva, A" uniqKey="Villanueva A" first="A" last="Villanueva">A. Villanueva</name><affiliation wicri:level="3"><nlm:affiliation>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Gomis, R R" sort="Gomis, R R" uniqKey="Gomis R" first="R R" last="Gomis">R R Gomis</name><affiliation wicri:level="3"><nlm:affiliation>Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pujana, M A" sort="Pujana, M A" uniqKey="Pujana M" first="M A" last="Pujana">M A Pujana</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27991928</idno><idno type="pmid">27991928</idno><idno type="doi">10.1038/onc.2016.427</idno><idno type="pmc">PMC5442428</idno><idno type="wicri:Area/Main/Corpus">000913</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000913</idno><idno type="wicri:Area/Main/Curation">000913</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000913</idno><idno type="wicri:Area/Main/Exploration">000913</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.</title><author><name sortKey="Mateo, F" sort="Mateo, F" uniqKey="Mateo F" first="F" last="Mateo">F. Mateo</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Arenas, E J" sort="Arenas, E J" uniqKey="Arenas E" first="E J" last="Arenas">E J Arenas</name><affiliation wicri:level="3"><nlm:affiliation>Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Aguilar, H" sort="Aguilar, H" uniqKey="Aguilar H" first="H" last="Aguilar">H. Aguilar</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Serra Musach, J" sort="Serra Musach, J" uniqKey="Serra Musach J" first="J" last="Serra-Musach">J. Serra-Musach</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="De Garibay, G Ruiz" sort="De Garibay, G Ruiz" uniqKey="De Garibay G" first="G Ruiz" last="De Garibay">G Ruiz De Garibay</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Boni, J" sort="Boni, J" uniqKey="Boni J" first="J" last="Boni">J. Boni</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Maicas, M" sort="Maicas, M" uniqKey="Maicas M" first="M" last="Maicas">M. Maicas</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Medical Research (CIMA) and Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Applied Medical Research (CIMA) and Department of Biochemistry and Genetics, University of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Du, S" sort="Du, S" uniqKey="Du S" first="S" last="Du">S. Du</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiation Oncology, New York University School of Medicine, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, New York University School of Medicine, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Iorio, F" sort="Iorio, F" uniqKey="Iorio F" first="F" last="Iorio">F. Iorio</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation></author><author><name sortKey="Herranz Ors, C" sort="Herranz Ors, C" uniqKey="Herranz Ors C" first="C" last="Herranz-Ors">C. Herranz-Ors</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Islam, A" sort="Islam, A" uniqKey="Islam A" first="A" last="Islam">A. Islam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh.</nlm:affiliation><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka</wicri:regionArea><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="Prado, X" sort="Prado, X" uniqKey="Prado X" first="X" last="Prado">X. Prado</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Llorente, A" sort="Llorente, A" uniqKey="Llorente A" first="A" last="Llorente">A. Llorente</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Petit, A" sort="Petit, A" uniqKey="Petit A" first="A" last="Petit">A. Petit</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Vidal, A" sort="Vidal, A" uniqKey="Vidal A" first="A" last="Vidal">A. Vidal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Catala, I" sort="Catala, I" uniqKey="Catala I" first="I" last="Català">I. Català</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Soler, T" sort="Soler, T" uniqKey="Soler T" first="T" last="Soler">T. Soler</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Venturas, G" sort="Venturas, G" uniqKey="Venturas G" first="G" last="Venturas">G. Venturas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rojo Sebastian, A" sort="Rojo Sebastian, A" uniqKey="Rojo Sebastian A" first="A" last="Rojo-Sebastian">A. Rojo-Sebastian</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, MD Anderson Cancer Center, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, MD Anderson Cancer Center, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Serra, H" sort="Serra, H" uniqKey="Serra H" first="H" last="Serra">H. Serra</name><affiliation wicri:level="3"><nlm:affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cuadras, D" sort="Cuadras, D" uniqKey="Cuadras D" first="D" last="Cuadras">D. Cuadras</name><affiliation wicri:level="3"><nlm:affiliation>Statistics Unit, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Statistics Unit, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Blanco, I" sort="Blanco, I" uniqKey="Blanco I" first="I" last="Blanco">I. Blanco</name><affiliation wicri:level="3"><nlm:affiliation>Hereditary Cancer Programme, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hereditary Cancer Programme, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lozano, J" sort="Lozano, J" uniqKey="Lozano J" first="J" last="Lozano">J. Lozano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Biology and Biochemistry, Málaga University, and Molecular Oncology Laboratory, Mediterranean Institute for the Advance of Biotechnology and Health Research (IBIMA), University Hospital Virgen de la Victoria, Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Molecular Biology and Biochemistry, Málaga University, and Molecular Oncology Laboratory, Mediterranean Institute for the Advance of Biotechnology and Health Research (IBIMA), University Hospital Virgen de la Victoria, Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Canals, F" sort="Canals, F" uniqKey="Canals F" first="F" last="Canals">F. Canals</name><affiliation wicri:level="3"><nlm:affiliation>ProteoRed-Instituto de Salud Carlos III, Proteomic Laboratory, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>ProteoRed-Instituto de Salud Carlos III, Proteomic Laboratory, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sieuwerts, A M" sort="Sieuwerts, A M" uniqKey="Sieuwerts A" first="A M" last="Sieuwerts">A M Sieuwerts</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Weerd, V" sort="De Weerd, V" uniqKey="De Weerd V" first="V" last="De Weerd">V. De Weerd</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Look, M P" sort="Look, M P" uniqKey="Look M" first="M P" last="Look">M P Look</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Puertas, S" sort="Puertas, S" uniqKey="Puertas S" first="S" last="Puertas">S. Puertas</name><affiliation wicri:level="3"><nlm:affiliation>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Garcia, N" sort="Garcia, N" uniqKey="Garcia N" first="N" last="García">N. García</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Perkins, A S" sort="Perkins, A S" uniqKey="Perkins A" first="A S" last="Perkins">A S Perkins</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Bonifaci, N" sort="Bonifaci, N" uniqKey="Bonifaci N" first="N" last="Bonifaci">N. Bonifaci</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Skowron, M" sort="Skowron, M" uniqKey="Skowron M" first="M" last="Skowron">M. Skowron</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="G Mez Bald, L" sort="G Mez Bald, L" uniqKey="G Mez Bald L" first="L" last="G Mez-Bald">L. G Mez-Bald</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hernandez, V" sort="Hernandez, V" uniqKey="Hernandez V" first="V" last="Hernández">V. Hernández</name><affiliation wicri:level="3"><nlm:affiliation>Biological Clues of the Invasive and Metastatic Phenotype Laboratory, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Biological Clues of the Invasive and Metastatic Phenotype Laboratory, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martinez Aranda, A" sort="Martinez Aranda, A" uniqKey="Martinez Aranda A" first="A" last="Martínez-Aranda">A. Martínez-Aranda</name><affiliation wicri:level="3"><nlm:affiliation>Biological Clues of the Invasive and Metastatic Phenotype Laboratory, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Biological Clues of the Invasive and Metastatic Phenotype Laboratory, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martinez Iniesta, M" sort="Martinez Iniesta, M" uniqKey="Martinez Iniesta M" first="M" last="Martínez-Iniesta">M. Martínez-Iniesta</name><affiliation wicri:level="3"><nlm:affiliation>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Serrat, X" sort="Serrat, X" uniqKey="Serrat X" first="X" last="Serrat">X. Serrat</name><affiliation wicri:level="3"><nlm:affiliation>Cancer and Human Molecular Genetics, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer and Human Molecular Genetics, IDIBELL, Hospitalet de Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cer N, J" sort="Cer N, J" uniqKey="Cer N J" first="J" last="Cer N">J. Cer N</name><affiliation wicri:level="3"><nlm:affiliation>Cancer and Human Molecular Genetics, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer and Human Molecular Genetics, IDIBELL, Hospitalet de Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Brunet, J" sort="Brunet, J" uniqKey="Brunet J" first="J" last="Brunet">J. Brunet</name><affiliation wicri:level="1"><nlm:affiliation>Hereditary Cancer Programme, ICO, Girona Biomedical Research Institute (IDIBGI), Girona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hereditary Cancer Programme, ICO, Girona Biomedical Research Institute (IDIBGI), Girona</wicri:regionArea><wicri:noRegion>Girona</wicri:noRegion></affiliation></author><author><name sortKey="Barretina, M P" sort="Barretina, M P" uniqKey="Barretina M" first="M P" last="Barretina">M P Barretina</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBGI, Girona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBGI, Girona</wicri:regionArea><wicri:noRegion>Girona</wicri:noRegion></affiliation></author><author><name sortKey="Gil, M" sort="Gil, M" uniqKey="Gil M" first="M" last="Gil">M. Gil</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Falo, C" sort="Falo, C" uniqKey="Falo C" first="C" last="Falo">C. Falo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Fernandez, A" sort="Fernandez, A" uniqKey="Fernandez A" first="A" last="Fernández">A. Fernández</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Morilla, I" sort="Morilla, I" uniqKey="Morilla I" first="I" last="Morilla">I. Morilla</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pernas, S" sort="Pernas, S" uniqKey="Pernas S" first="S" last="Pernas">S. Pernas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pla, M J" sort="Pla, M J" uniqKey="Pla M" first="M J" last="Plà">M J Plà</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gynecology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Gynecology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Andreu, X" sort="Andreu, X" uniqKey="Andreu X" first="X" last="Andreu">X. Andreu</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Parc Taulí Hospital Consortium, Sabadell, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, Parc Taulí Hospital Consortium, Sabadell, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Segui, M A" sort="Segui, M A" uniqKey="Segui M" first="M A" last="Seguí">M A Seguí</name><affiliation wicri:level="3"><nlm:affiliation>Medical Oncology Service, Parc Taulí Hospital Consortium, Sabadell, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Medical Oncology Service, Parc Taulí Hospital Consortium, Sabadell, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ballester, R" sort="Ballester, R" uniqKey="Ballester R" first="R" last="Ballester">R. Ballester</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation Oncology, University Hospital Germans Trias i Pujol, ICO, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Radiation Oncology, University Hospital Germans Trias i Pujol, ICO, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Castella, E" sort="Castella, E" uniqKey="Castella E" first="E" last="Castellà">E. Castellà</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital Germans Trias i Pujol, ICO, IGTP, Badalona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital Germans Trias i Pujol, ICO, IGTP, Badalona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Nellist, M" sort="Nellist, M" uniqKey="Nellist M" first="M" last="Nellist">M. Nellist</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Morales, S" sort="Morales, S" uniqKey="Morales S" first="S" last="Morales">S. Morales</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Valls, J" sort="Valls, J" uniqKey="Valls J" first="J" last="Valls">J. Valls</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Velasco, A" sort="Velasco, A" uniqKey="Velasco A" first="A" last="Velasco">A. Velasco</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Matias Guiu, X" sort="Matias Guiu, X" uniqKey="Matias Guiu X" first="X" last="Matias-Guiu">X. Matias-Guiu</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Figueras, A" sort="Figueras, A" uniqKey="Figueras A" first="A" last="Figueras">A. Figueras</name><affiliation wicri:level="3"><nlm:affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez Mut, J V" sort="Sanchez Mut, J V" uniqKey="Sanchez Mut J" first="J V" last="Sánchez-Mut">J V Sánchez-Mut</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez Cespedes, M" sort="Sanchez Cespedes, M" uniqKey="Sanchez Cespedes M" first="M" last="Sánchez-Céspedes">M. Sánchez-Céspedes</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cordero, A" sort="Cordero, A" uniqKey="Cordero A" first="A" last="Cordero">A. Cordero</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="G Mez Miragaya, J" sort="G Mez Miragaya, J" uniqKey="G Mez Miragaya J" first="J" last="G Mez-Miragaya">J. G Mez-Miragaya</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Palomero, L" sort="Palomero, L" uniqKey="Palomero L" first="L" last="Palomero">L. Palomero</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="G Mez, A" sort="G Mez, A" uniqKey="G Mez A" first="A" last="G Mez">A. G Mez</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Gajewski, T F" sort="Gajewski, T F" uniqKey="Gajewski T" first="T F" last="Gajewski">T F Gajewski</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Pathology and Medicine, University of Chicago, Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pathology and Medicine, University of Chicago, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Cohen, E E W" sort="Cohen, E E W" uniqKey="Cohen E" first="E E W" last="Cohen">E E W. Cohen</name><affiliation wicri:level="2"><nlm:affiliation>Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moores Cancer Center, University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jesiotr, M" sort="Jesiotr, M" uniqKey="Jesiotr M" first="M" last="Jesiotr">M. Jesiotr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Military Institute of Medicine, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pathology, Military Institute of Medicine, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Bodnar, L" sort="Bodnar, L" uniqKey="Bodnar L" first="L" last="Bodnar">L. Bodnar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Military Institute of Medicine, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Oncology, Military Institute of Medicine, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Quintela Fandino, M" sort="Quintela Fandino, M" uniqKey="Quintela Fandino M" first="M" last="Quintela-Fandino">M. Quintela-Fandino</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer Clinical Research Unit, Spanish National Cancer Research Center (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer Clinical Research Unit, Spanish National Cancer Research Center (CNIO), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="L Pez Bigas, N" sort="L Pez Bigas, N" uniqKey="L Pez Bigas N" first="N" last="L Pez-Bigas">N. L Pez-Bigas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Experimental and Health Sciences, Barcelona Biomedical Research Park, Pompeu Fabra University (UPF), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Experimental and Health Sciences, Barcelona Biomedical Research Park, Pompeu Fabra University (UPF), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Valdes Mas, R" sort="Valdes Mas, R" uniqKey="Valdes Mas R" first="R" last="Valdés-Mas">R. Valdés-Mas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, University Institute of Oncology of Asturias, University of Oviedo, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, University Institute of Oncology of Asturias, University of Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Puente, X S" sort="Puente, X S" uniqKey="Puente X" first="X S" last="Puente">X S Puente</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, University Institute of Oncology of Asturias, University of Oviedo, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, University Institute of Oncology of Asturias, University of Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Vi Als, F" sort="Vi Als, F" uniqKey="Vi Als F" first="F" last="Vi Als">F. Vi Als</name><affiliation wicri:level="3"><nlm:affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Casanovas, O" sort="Casanovas, O" uniqKey="Casanovas O" first="O" last="Casanovas">O. Casanovas</name><affiliation wicri:level="3"><nlm:affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Graupera, M" sort="Graupera, M" uniqKey="Graupera M" first="M" last="Graupera">M. Graupera</name><affiliation wicri:level="3"><nlm:affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hernandez Losa, J" sort="Hernandez Losa, J" uniqKey="Hernandez Losa J" first="J" last="Hernández-Losa">J. Hernández-Losa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, Vall d'Hebron University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ram N Y Cajal, S" sort="Ram N Y Cajal, S" uniqKey="Ram N Y Cajal S" first="S" last="Ram N Y Cajal">S. Ram N Y Cajal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, Vall d'Hebron University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Garcia Alonso, L" sort="Garcia Alonso, L" uniqKey="Garcia Alonso L" first="L" last="García-Alonso">L. García-Alonso</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Saez Rodriguez, J" sort="Saez Rodriguez, J" uniqKey="Saez Rodriguez J" first="J" last="Saez-Rodriguez">J. Saez-Rodriguez</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Esteller, M" sort="Esteller, M" uniqKey="Esteller M" first="M" last="Esteller">M. Esteller</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sierra, A" sort="Sierra, A" uniqKey="Sierra A" first="A" last="Sierra">A. Sierra</name><affiliation wicri:level="3"><nlm:affiliation>Molecular and Translational Oncology Laboratory, Biomedical Research Center CELLEX-CRBC, Biomedical Research Institute 'August Pi i Sunyer' (IDIBAPS), and Systems Biology Department, Faculty of Science and Technology, University of Vic, Central University of Catalonia, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Molecular and Translational Oncology Laboratory, Biomedical Research Center CELLEX-CRBC, Biomedical Research Institute 'August Pi i Sunyer' (IDIBAPS), and Systems Biology Department, Faculty of Science and Technology, University of Vic, Central University of Catalonia, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martin Martin, N" sort="Martin Martin, N" uniqKey="Martin Martin N" first="N" last="Martín-Martín">N. Martín-Martín</name><affiliation wicri:level="1"><nlm:affiliation>Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio</wicri:regionArea><wicri:noRegion>Derio</wicri:noRegion></affiliation></author><author><name sortKey="Matheu, A" sort="Matheu, A" uniqKey="Matheu A" first="A" last="Matheu">A. Matheu</name><affiliation wicri:level="1"><nlm:affiliation>Neuro-Oncology Section, Oncology Department, Biodonostia Research Institute, San Sebastian, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neuro-Oncology Section, Oncology Department, Biodonostia Research Institute, San Sebastian</wicri:regionArea><wicri:noRegion>San Sebastian</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Ikerbasque, Basque Foundation for Science, Bilbao, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Ikerbasque, Basque Foundation for Science, Bilbao</wicri:regionArea><wicri:noRegion>Bilbao</wicri:noRegion></affiliation></author><author><name sortKey="Carracedo, A" sort="Carracedo, A" uniqKey="Carracedo A" first="A" last="Carracedo">A. Carracedo</name><affiliation wicri:level="1"><nlm:affiliation>Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio</wicri:regionArea><wicri:noRegion>Derio</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Ikerbasque, Basque Foundation for Science, Bilbao, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Ikerbasque, Basque Foundation for Science, Bilbao</wicri:regionArea><wicri:noRegion>Bilbao</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Bilbao, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Bilbao</wicri:regionArea><wicri:noRegion>Bilbao</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Suarez, E" sort="Gonzalez Suarez, E" uniqKey="Gonzalez Suarez E" first="E" last="González-Suárez">E. González-Suárez</name><affiliation wicri:level="3"><nlm:affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Nanjundan, M" sort="Nanjundan, M" uniqKey="Nanjundan M" first="M" last="Nanjundan">M. Nanjundan</name><affiliation wicri:level="4"><nlm:affiliation>Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL</wicri:regionArea><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation></author><author><name sortKey="Cortes, J" sort="Cortes, J" uniqKey="Cortes J" first="J" last="Cortés">J. Cortés</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, VHIO, Vall d'Hebron University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, VHIO, Vall d'Hebron University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lazaro, C" sort="Lazaro, C" uniqKey="Lazaro C" first="C" last="Lázaro">C. Lázaro</name><affiliation wicri:level="3"><nlm:affiliation>Hereditary Cancer Programme, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hereditary Cancer Programme, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Odero, M D" sort="Odero, M D" uniqKey="Odero M" first="M D" last="Odero">M D Odero</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Medical Research (CIMA) and Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Applied Medical Research (CIMA) and Department of Biochemistry and Genetics, University of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Martens, J W M" sort="Martens, J W M" uniqKey="Martens J" first="J W M" last="Martens">J W M. Martens</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Moreno Bueno, G" sort="Moreno Bueno, G" uniqKey="Moreno Bueno G" first="G" last="Moreno-Bueno">G. Moreno-Bueno</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biochemistry, Autonomous University of Madrid (UAM), Biomedical Research Institute 'Alberto Sols' (Spanish National Research Council (CSIC)-UAM), Translational Research Laboratory, Hospital La Paz Institute for Health Research (IdiPAZ), and MD Anderson International Foundation, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry, Autonomous University of Madrid (UAM), Biomedical Research Institute 'Alberto Sols' (Spanish National Research Council (CSIC)-UAM), Translational Research Laboratory, Hospital La Paz Institute for Health Research (IdiPAZ), and MD Anderson International Foundation, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Barcellos Hoff, M H" sort="Barcellos Hoff, M H" uniqKey="Barcellos Hoff M" first="M H" last="Barcellos-Hoff">M H Barcellos-Hoff</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiation Oncology, New York University School of Medicine, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, New York University School of Medicine, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Villanueva, A" sort="Villanueva, A" uniqKey="Villanueva A" first="A" last="Villanueva">A. Villanueva</name><affiliation wicri:level="3"><nlm:affiliation>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Gomis, R R" sort="Gomis, R R" uniqKey="Gomis R" first="R R" last="Gomis">R R Gomis</name><affiliation wicri:level="3"><nlm:affiliation>Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pujana, M A" sort="Pujana, M A" uniqKey="Pujana M" first="M A" last="Pujana">M A Pujana</name><affiliation wicri:level="3"><nlm:affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><series><title level="j">Oncogene</title><idno type="eISSN">1476-5594</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptor Proteins, Signal Transducing (genetics)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Breast Neoplasms (genetics)</term><term>Breast Neoplasms (pathology)</term><term>Carrier Proteins (genetics)</term><term>Cell Proliferation (genetics)</term><term>DNA-Binding Proteins (genetics)</term><term>Female (MeSH)</term><term>Gene Expression Regulation, Neoplastic (MeSH)</term><term>Humans (MeSH)</term><term>Lung Neoplasms (genetics)</term><term>Lung Neoplasms (pathology)</term><term>Lung Neoplasms (secondary)</term><term>MCF-7 Cells (MeSH)</term><term>MDS1 and EVI1 Complex Locus Protein (MeSH)</term><term>Microfilament Proteins (genetics)</term><term>Middle Aged (MeSH)</term><term>Neoplasm Metastasis (MeSH)</term><term>Osteonectin (genetics)</term><term>Proto-Oncogenes (genetics)</term><term>Regulatory-Associated Protein of mTOR (MeSH)</term><term>SOX9 Transcription Factor (genetics)</term><term>Signal Transduction (genetics)</term><term>TOR Serine-Threonine Kinases (antagonists & inhibitors)</term><term>TOR Serine-Threonine Kinases (genetics)</term><term>Transcription Factors (genetics)</term><term>Xenograft Model Antitumor Assays (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Cellules MCF-7 (MeSH)</term><term>Facteur de transcription SOX-9 (génétique)</term><term>Facteurs de transcription (génétique)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Métastase tumorale (MeSH)</term><term>Ostéonectine (génétique)</term><term>Prolifération cellulaire (génétique)</term><term>Proto-oncogènes (génétique)</term><term>Protéine de régulation associée à mTOR (MeSH)</term><term>Protéine du locus du complexe MDS1 et EVI1 (MeSH)</term><term>Protéines adaptatrices de la transduction du signal (génétique)</term><term>Protéines de liaison à l'ADN (génétique)</term><term>Protéines de transport (génétique)</term><term>Protéines des microfilaments (génétique)</term><term>Régulation de l'expression des gènes tumoraux (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sérine-thréonine kinases TOR (antagonistes et inhibiteurs)</term><term>Sérine-thréonine kinases TOR (génétique)</term><term>Tests d'activité antitumorale sur modèle de xénogreffe (MeSH)</term><term>Transduction du signal (génétique)</term><term>Tumeurs du poumon (anatomopathologie)</term><term>Tumeurs du poumon (génétique)</term><term>Tumeurs du poumon (secondaire)</term><term>Tumeurs du sein (anatomopathologie)</term><term>Tumeurs du sein (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term><term>Carrier Proteins</term><term>DNA-Binding Proteins</term><term>Microfilament Proteins</term><term>Osteonectin</term><term>SOX9 Transcription Factor</term><term>TOR Serine-Threonine Kinases</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du poumon</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term><term>Cell Proliferation</term><term>Lung Neoplasms</term><term>Proto-Oncogenes</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de transcription SOX-9</term><term>Facteurs de transcription</term><term>Ostéonectine</term><term>Prolifération cellulaire</term><term>Proto-oncogènes</term><term>Protéines adaptatrices de la transduction du signal</term><term>Protéines de liaison à l'ADN</term><term>Protéines de transport</term><term>Protéines des microfilaments</term><term>Sérine-thréonine kinases TOR</term><term>Transduction du signal</term><term>Tumeurs du poumon</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Gene Expression Regulation, Neoplastic</term><term>Humans</term><term>MCF-7 Cells</term><term>MDS1 and EVI1 Complex Locus Protein</term><term>Middle Aged</term><term>Neoplasm Metastasis</term><term>Regulatory-Associated Protein of mTOR</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cellules MCF-7</term><term>Femelle</term><term>Humains</term><term>Métastase tumorale</term><term>Protéine de régulation associée à mTOR</term><term>Protéine du locus du complexe MDS1 et EVI1</term><term>Régulation de l'expression des gènes tumoraux</term><term>Sujet âgé</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Inhibitors of the mechanistic target of rapamycin (mTOR) are currently used to treat advanced metastatic breast cancer. However, whether an aggressive phenotype is sustained through adaptation or resistance to mTOR inhibition remains unknown. Here, complementary studies in human tumors, cancer models and cell lines reveal transcriptional reprogramming that supports metastasis in response to mTOR inhibition. This cancer feature is driven by EVI1 and SOX9. EVI1 functionally cooperates with and positively regulates SOX9, and promotes the transcriptional upregulation of key mTOR pathway components (REHB and RAPTOR) and of lung metastasis mediators (FSCN1 and SPARC). The expression of EVI1 and SOX9 is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR targeting failure.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27991928</PMID><DateCompleted><Year>2017</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-5594</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>19</Issue><PubDate><Year>2017</Year><Month>05</Month><Day>11</Day></PubDate></JournalIssue><Title>Oncogene</Title><ISOAbbreviation>Oncogene</ISOAbbreviation></Journal><ArticleTitle>Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.</ArticleTitle><Pagination><MedlinePgn>2737-2749</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/onc.2016.427</ELocationID><Abstract><AbstractText>Inhibitors of the mechanistic target of rapamycin (mTOR) are currently used to treat advanced metastatic breast cancer. However, whether an aggressive phenotype is sustained through adaptation or resistance to mTOR inhibition remains unknown. Here, complementary studies in human tumors, cancer models and cell lines reveal transcriptional reprogramming that supports metastasis in response to mTOR inhibition. This cancer feature is driven by EVI1 and SOX9. EVI1 functionally cooperates with and positively regulates SOX9, and promotes the transcriptional upregulation of key mTOR pathway components (REHB and RAPTOR) and of lung metastasis mediators (FSCN1 and SPARC). The expression of EVI1 and SOX9 is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR targeting failure.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mateo</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arenas</LastName><ForeName>E J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aguilar</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Serra-Musach</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Garibay</LastName><ForeName>G Ruiz</ForeName><Initials>GR</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boni</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maicas</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Applied Medical Research (CIMA) and Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, New York University School of Medicine, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iorio</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herranz-Ors</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Islam</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prado</LastName><ForeName>X</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Llorente</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petit</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vidal</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Català</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soler</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venturas</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rojo-Sebastian</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathology, MD Anderson Cancer Center, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Serra</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cuadras</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Statistics Unit, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blanco</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Hereditary Cancer Programme, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lozano</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Molecular Biology and Biochemistry, Málaga University, and Molecular Oncology Laboratory, Mediterranean Institute for the Advance of Biotechnology and Health Research (IBIMA), University Hospital Virgen de la Victoria, Málaga, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Canals</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>ProteoRed-Instituto de Salud Carlos III, Proteomic Laboratory, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sieuwerts</LastName><ForeName>A M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Weerd</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Look</LastName><ForeName>M P</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Puertas</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perkins</LastName><ForeName>A S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonifaci</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Skowron</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gómez-Baldó</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernández</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Biological Clues of the Invasive and Metastatic Phenotype Laboratory, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez-Aranda</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Biological Clues of the Invasive and Metastatic Phenotype Laboratory, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez-Iniesta</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Serrat</LastName><ForeName>X</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Cancer and Human Molecular Genetics, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerón</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Cancer and Human Molecular Genetics, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brunet</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hereditary Cancer Programme, ICO, Girona Biomedical Research Institute (IDIBGI), Girona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barretina</LastName><ForeName>M P</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, ICO, IDIBGI, Girona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gil</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Falo</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morilla</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pernas</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plà</LastName><ForeName>M J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Gynecology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andreu</LastName><ForeName>X</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Pathology, Parc Taulí Hospital Consortium, Sabadell, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seguí</LastName><ForeName>M A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Medical Oncology Service, Parc Taulí Hospital Consortium, Sabadell, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ballester</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, University Hospital Germans Trias i Pujol, ICO, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castellà</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Pathology, University Hospital Germans Trias i Pujol, ICO, IGTP, Badalona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nellist</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morales</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valls</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Velasco</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matias-Guiu</LastName><ForeName>X</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Hospital Arnau de Vilanova, University of Lleida, Biomedical Research Institute of Lleida (IRB Lleida), Lleida, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Figueras</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sánchez-Mut</LastName><ForeName>J V</ForeName><Initials>JV</Initials><AffiliationInfo><Affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sánchez-Céspedes</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cordero</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gómez-Miragaya</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palomero</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gómez</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gajewski</LastName><ForeName>T F</ForeName><Initials>TF</Initials><AffiliationInfo><Affiliation>Departments of Pathology and Medicine, University of Chicago, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cohen</LastName><ForeName>E E W</ForeName><Initials>EEW</Initials><AffiliationInfo><Affiliation>Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jesiotr</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, Military Institute of Medicine, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bodnar</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Oncology, Military Institute of Medicine, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quintela-Fandino</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Breast Cancer Clinical Research Unit, Spanish National Cancer Research Center (CNIO), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-Bigas</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Experimental and Health Sciences, Barcelona Biomedical Research Park, Pompeu Fabra University (UPF), Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valdés-Mas</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University Institute of Oncology of Asturias, University of Oviedo, Oviedo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Puente</LastName><ForeName>X S</ForeName><Initials>XS</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University Institute of Oncology of Asturias, University of Oviedo, Oviedo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viñals</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casanovas</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Graupera</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Angiogenesis Research Group, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernández-Losa</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramón Y Cajal</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, Vall d'Hebron University Hospital, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Alonso</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saez-Rodriguez</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esteller</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sierra</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Molecular and Translational Oncology Laboratory, Biomedical Research Center CELLEX-CRBC, Biomedical Research Institute 'August Pi i Sunyer' (IDIBAPS), and Systems Biology Department, Faculty of Science and Technology, University of Vic, Central University of Catalonia, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martín-Martín</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matheu</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Neuro-Oncology Section, Oncology Department, Biodonostia Research Institute, San Sebastian, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Ikerbasque, Basque Foundation for Science, Bilbao, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carracedo</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Ikerbasque, Basque Foundation for Science, Bilbao, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Bilbao, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>González-Suárez</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nanjundan</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cortés</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, VHIO, Vall d'Hebron University Hospital, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lázaro</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hereditary Cancer Programme, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Odero</LastName><ForeName>M D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Centre for Applied Medical Research (CIMA) and Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martens</LastName><ForeName>J W M</ForeName><Initials>JWM</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Cancer Genomics Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moreno-Bueno</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Autonomous University of Madrid (UAM), Biomedical Research Institute 'Alberto Sols' (Spanish National Research Council (CSIC)-UAM), Translational Research Laboratory, Hospital La Paz Institute for Health Research (IdiPAZ), and MD Anderson International Foundation, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barcellos-Hoff</LastName><ForeName>M H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, New York University School of Medicine, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villanueva</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Chemoresistance and Predictive Factors Laboratory, ProCURE, ICO, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gomis</LastName><ForeName>R R</ForeName><Initials>RR</Initials><AffiliationInfo><Affiliation>Oncology Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pujana</LastName><ForeName>M A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Breast Cancer and Systems Biology Laboratory, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>12</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Oncogene</MedlineTA><NlmUniqueID>8711562</NlmUniqueID><ISSNLinking>0950-9232</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D048868">Adaptor Proteins, Signal Transducing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004268">DNA-Binding Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C502658">FSCN1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000074008">MDS1 and EVI1 Complex Locus Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C063575">MECOM 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Villanueva</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Du, S" sort="Du, S" uniqKey="Du S" first="S" last="Du">S. Du</name></region><name sortKey="Barcellos Hoff, M H" sort="Barcellos Hoff, M H" uniqKey="Barcellos Hoff M" first="M H" last="Barcellos-Hoff">M H Barcellos-Hoff</name><name sortKey="Cohen, E E W" sort="Cohen, E E W" uniqKey="Cohen E" first="E E W" last="Cohen">E E W. Cohen</name><name sortKey="Gajewski, T F" sort="Gajewski, T F" uniqKey="Gajewski T" first="T F" last="Gajewski">T F Gajewski</name><name sortKey="Nanjundan, M" sort="Nanjundan, M" uniqKey="Nanjundan M" first="M" last="Nanjundan">M. Nanjundan</name><name sortKey="Perkins, A S" sort="Perkins, A S" uniqKey="Perkins A" first="A S" last="Perkins">A S Perkins</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Iorio, F" sort="Iorio, F" uniqKey="Iorio F" first="F" last="Iorio">F. Iorio</name></noRegion><name sortKey="Garcia Alonso, L" sort="Garcia Alonso, L" uniqKey="Garcia Alonso L" first="L" last="García-Alonso">L. García-Alonso</name><name sortKey="Iorio, F" sort="Iorio, F" uniqKey="Iorio F" first="F" last="Iorio">F. Iorio</name><name sortKey="Saez Rodriguez, J" sort="Saez Rodriguez, J" uniqKey="Saez Rodriguez J" first="J" last="Saez-Rodriguez">J. Saez-Rodriguez</name></country><country name="Bangladesh"><noRegion><name sortKey="Islam, A" sort="Islam, A" uniqKey="Islam A" first="A" last="Islam">A. Islam</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Sieuwerts, A M" sort="Sieuwerts, A M" uniqKey="Sieuwerts A" first="A M" last="Sieuwerts">A M Sieuwerts</name></region><name sortKey="De Weerd, V" sort="De Weerd, V" uniqKey="De Weerd V" first="V" last="De Weerd">V. De Weerd</name><name sortKey="Look, M P" sort="Look, M P" uniqKey="Look M" first="M P" last="Look">M P Look</name><name sortKey="Martens, J W M" sort="Martens, J W M" uniqKey="Martens J" first="J W M" last="Martens">J W M. Martens</name><name sortKey="Nellist, M" sort="Nellist, M" uniqKey="Nellist M" first="M" last="Nellist">M. Nellist</name></country><country name="Pologne"><noRegion><name sortKey="Jesiotr, M" sort="Jesiotr, M" uniqKey="Jesiotr M" first="M" last="Jesiotr">M. Jesiotr</name></noRegion><name sortKey="Bodnar, L" sort="Bodnar, L" uniqKey="Bodnar L" first="L" last="Bodnar">L. Bodnar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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